TNF receptor 1 gene variant could explain failure of TNF-blocking drugs in multiple sclerosis
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چکیده
منابع مشابه
Comment on: Failure of anti-TNF therapy in TNF receptor 1-associated periodic syndrome (TRAPS).
There was no history of ischaemic heart disease, but a routine ECG performed in April 2006 showed first-degree heart block, at a rate of 70 beats/min. Patients having infliximab in our unit are admitted overnight for the first three infusions. The first infusion was uneventful at week 0. Following the second infusion 2 weeks later, she then gave a history of dry cough for 3–4 months. A chest X-...
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*Department of Anatomy, Physiology, and Genetics and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814; †Cancer and Cell Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and §Protein Expression Laboratory, National Cancer Institute SAIC, Nationa...
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Background and purpose: Multiple sclerosis (MS) is a chronic autoimmune disease in which the myelin sheaths of nerve cells in the brain and spinal cord are damaged. The prevalence of disease is higher in women and it seems that sex hormones, which usually exert their effects through receptors, are involved in susceptibility to MS. Considering the functional role of Alu insertion 306 bp polymorp...
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ژورنال
عنوان ژورنال: Nature Reviews Neurology
سال: 2012
ISSN: 1759-4758,1759-4766
DOI: 10.1038/nrneurol.2012.149